At present we do not have much information about Shirlin lines, or relations with Cherlins, Tsirlins, and others.
There are 10 listings from the Social Security death index falling mainly into two groups of people who used the Shirlin spelling as their official name.
We also have two entries on Ellis Island immigration manifests (1906). These are Dobisch and Rivke Shirlin. The same record gives the husband's name (already in the U.S.) as Sherlin. Their Ellis Island records are here
Dobisch was the mother, and Rivke the wife, of a man listed as Israel Scherlin and living on Antoine St, Detroit, Michigan. This could be the Ize Scherlin listed on a 1904 manifest, but as he came from Vitebsk in the north, and they came from Khodorkov, way south near Kiev, it seems unlikely. The possibility that Ize was Isadore Cherlin, though far from certain, is geographically more likely.
Corrected April 2003